ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
The Synergy between Topography and Lipid Domains in the Plasma Membrane of Mast Cells Controls the Localization of Signaling Proteins and Facilitates their Coordinated Activation
Shirsendu Ghosh, Alice Wagenknecht-Wiesner, Shriya Desai…·Barbara A. Baird
This paper shows that ordered lipid nanodomains and microvilli in mast cells coordinate to localize signaling proteins, enabling efficient antigen-triggered immune responses.