Author

J. L. Guler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Brown· 2 shared J. A. Papin· 2 shared M. A. Carey· 2 shared A. Aryal· 1 shared A. C. Brown· 1 shared A. M. Untaroiu· 1 shared C. C. Moore· 1 shared G. L. Medlock· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

A. Brown

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Author profile →

4 papers

Recent·Most cited

Nutrient limitation mimics artemisinin tolerance in malaria

A. Brown, M. D. Warthan, A. Aryal, S. Liu, J. L. Guler

This study shows that nutrient limitation increases malaria parasite tolerance to the drug dihydroartemisinin, mimicking genetic resistance mechanisms.

bioRxiv · Jun 14, 2022Microbiology

Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites

A. C. Brown, C. C. Moore, J. L. Guler

This paper introduces a method to enrich all Plasmodium-infected erythrocytes, including understudied ring stages, using SLO-Percoll (SLOPE) and demonstrates its effectiveness across multiple stages and media.

Scientific Reports · Mar 12, 2020Peer-reviewedMicrobiology

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

M. A. Carey, A. M. Untaroiu, J. L. Guler, J. A. Papin

This study identifies metabolic weaknesses in chloroquine-resistant malaria parasites and proposes combination therapies using chloroquine with sulfadoxine-pyrimethamine or fosmidomycin.

bioRxiv · Sep 26, 2018Microbiology

Influential parameters for the analysis of intracellular parasite metabolomics

M. A. Carey, V. Covelli, A. Brown, G. L. Medlock, M. Haaren, J. G. Cooper, J. A. Papin, J. L. Guler

This study identifies normalization parameters that significantly affect differential abundance analysis in metabolomics of intracellular parasites, highlighting the impact of host contamination.

bioRxiv · Feb 22, 2018Microbiology