Author

A. C. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Microbiology· 2 Biophysics· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

A. N. Singh· 2 shared J. B. Nice· 2 shared N. J. Wittenberg· 2 shared A. B. Featherstone· 1 shared A. J. Mathijssen· 1 shared A. Krissanaprasit· 1 shared A. Sinani· 1 shared A. Young· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersBioengineering

A. N. Singh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Engineering Planar Gram-Negative Outer Membrane Mimics Using Bacterial Outer Membrane Vesicles

A. N. Singh, M. Wu, T. T. Ye, A. C. Brown, N. J. Wittenberg

This study develops a method to create planar bacterial outer membrane mimics using OMVs, enabling antibiotic development studies by replicating the gram-negative membrane barrier.

bioRxiv · Dec 11, 2023Bioengineering

Simple Design for Membrane-Free Microphysiological Systems to Model the Blood-Tissue Barriers

A. Young, H. Deal, G. Rusch, V. Pozdin, A. C. Brown, M. Daniele

This paper introduces a membrane-free microphysiological system for modeling blood-tissue barriers, demonstrating a simple design that enables direct endothelial-epithelial contact and 3D transport.

bioRxiv · Oct 20, 2023Bioengineering

Toxin-Triggered Liposomes for the Controlled Release of Antibiotics to Treat Infections Associated with Gram-Negative Bacteria

Z. Li, R. Baidoun, A. C. Brown

This study develops a toxin-triggered liposomal system that releases antibiotics in response to LtxA from Gram-negative bacteria, showing selective release in LtxA-producing strains.

bioRxiv · Sep 28, 2023 · PreprintBioengineering

SARS-CoV-2 Delta Variant Remains Viable in Environmental Biofilms found in Meat Packaging Plants

S. Chitlapilly Dass, A. B. Featherstone, A. J. Mathijssen, A. C. Brown

This study shows SARS-CoV-2 Delta variant remains viable on surfaces in meat packaging plants, with some biofilms reducing its viability while others increasing it.

bioRxiv · Jun 15, 2023Ecology

Identifying size-dependent toxin sorting in bacterial outer membrane vesicles

A. N. Singh, J. B. Nice, A. C. Brown, N. J. Wittenberg

This study uses fluorescence imaging to show that larger OMVs from A. actinomycetemcomitans are more likely to contain leukotoxin, revealing size-dependent toxin sorting.

bioRxiv · May 3, 2023 · PreprintBiophysics

Separation of heterogeneous Aggregatibacter actinomycetemcomitans outer membrane vesicles reveals that toxin sorting is driven by surface-associated DNA

J. B. Nice, S. M. Collins, S. M. Agro, A. Sinani, S. D. Moros, L. M. Pasch, A. C. Brown

The paper investigates how surface-associated DNA drives the selective sorting of the toxin LtxA to large outer membrane vesicles in Aggregatibacter actinomycetemcomitans.

bioRxiv · Jul 11, 2022 · PreprintMicrobiology

Enhanced Anticoagulation Activity of Functional RNA Origami

A. Krissanaprasit, C. M. Key, K. Froehlich, S. Pontula, E. Mihalko, D. M. Dupont, E. S. Andersen, J. Kjems, A. C. Brown, T. H. LaBean

This paper develops RNA origami displaying RNA aptamers as anticoagulants, showing enhanced thrombin inhibition and reversible activity with potential for clinical use.

bioRxiv · Sep 29, 2020 · PreprintBioengineering

Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites

A. C. Brown, C. C. Moore, J. L. Guler

This paper introduces a method to enrich all Plasmodium-infected erythrocytes, including understudied ring stages, using SLO-Percoll (SLOPE) and demonstrates its effectiveness across multiple stages and media.

Scientific Reports · Mar 12, 2020Peer-reviewedMicrobiology