J. L. Hofmann

Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells

This study tracks ribosome-sized particles in E. coli to show that their 3D diffusion is influenced by macromolecular interactions and geometrical confinement, revealing sub-diffusive motion due to nucleoid and cell boundary constraints.

Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

The paper shows that ribosomal L12 subunits in E. coli increase translation rates by reducing diffusive search times for ternary complexes, but higher L12 copy numbers are not always beneficial for faster growth.

Ultra-weak protein-protein interactions can modulate proteome-wide searching and binding

The paper estimates ultra-weak protein-protein interactions and shows they can drive transient clusters and enhance protein association sampling in dense suspensions.