Author

J. P. Sheehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

B. P. Bratton· 2 shared Z. Gitai· 2 shared A. M. Sunol· 1 shared A. Mateus· 1 shared A. Typas· 1 shared B. M. Gitai· 1 shared D. Valverde-Mendez· 1 shared G. M. Moore· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiophysics

B. P. Bratton

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Author profile →

3 papers

Recent·Most cited

Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells

D. Valverde-Mendez, A. M. Sunol, B. P. Bratton, M. Delarue, J. L. Hofmann, J. P. Sheehan, Z. Gitai, L. J. Holt, J. W. Shaevitz, R. N. Zia

This study tracks ribosome-sized particles in E. coli to show that their 3D diffusion is influenced by macromolecular interactions and geometrical confinement, revealing sub-diffusive motion due to nucleoid and cell boundary constraints.

bioRxiv · Mar 27, 2024Biophysics

Analysis of E. coli growth dynamics during Lambda(vir) phage infection reveals phage decay

B. M. Gitai, J. P. Sheehan

This study repeats the Luria-Delbruck experiment using high-throughput spectrophotometry to analyze E. coli growth dynamics during Lambda(vir) phage infection, revealing phage decay and the impact of dead bacterial debris.

bioRxiv · Nov 28, 2023 · PreprintMicrobiology

A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance

J. K. Martin, M. Z. Wilson, G. M. Moore, J. P. Sheehan, A. Mateus, S. H.-J. Li, B. P. Bratton, H. Kim, J. D. Rabinowitz, A. Typas, M. M. Savitski, Z. Gitai

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

Cell · Jun 1, 2020Peer-reviewedMicrobiology