J. Leake

What is learned determines how Pavlovian conditioned fear is consolidated in the brain.

This study shows that protein synthesis in the BLA is required for first-order fear consolidation but not second-order fear, reflecting differences in what is learned during conditioning.

Contextual and temporal regulation of fear memory consolidation in the basolateral amygdala complex

This study shows that protein synthesis in the BLA is not always required for fear memory consolidation, depending on similarity to prior experiences, temporal distance, and context.

Danger changes the way the brain consolidates neutral information; and does so by interacting with processes involved in the encoding of that information.

This study shows that danger shifts memory consolidation of neutral information from the perirhinal cortex to the basolateral amygdala by altering encoding processes in rats.

Goal-directed action is transiently impaired in an hAPP-J20 mouse model of Alzheimer's disease, and in aging male mice regardless of genotype

The study shows that goal-directed action is temporarily impaired in Alzheimer's mouse models and aging males, linked to hippocampal neuroinflammation.