Carm1 regulates the speed of C/EBPa-induced transdifferentiation by a cofactor stealing mechanism
G. T. Garcia, E. Kowenz-Leutz, T. V. Tian, A. Klonizakis, J. Lerner, L. De Andres-Aguayo, C. Berenguer, M. P. Carmona, M. V. Casadesus, R. Bulteau, M. Francesconi, S. Peiro, K. S. Zaret, A. Leutz, T. Graf
This study shows that a C/EBP mutation accelerates B cell to macrophage transdifferentiation by altering PU.1 interactions, and that Carm1 methylation regulates this process.
bioRxiv · Oct 3, 2022Cell Biology