Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependant inter-ring crosstalks
J. Lesne, M. Locard-Paulet, J. Parra, D. Zivkovic, M.-P. Bousquet, O. Burlet-Schiltz, J. Marcoux
The paper uses HDX-MS to show conformational differences between human 20S proteasomes and their PA28 activators, revealing allosteric changes upon binding.
bioRxiv · May 5, 2020Biophysics