J. Marcoux

The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen

This study identifies LRP1 N-glycans with terminal galactoses as ligands for DCIR, revealing its specificity in immune regulation and potential therapeutic applications.

SURF2 is a MDM2 antagonist in triggering the nucleolar stress response

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.

LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry.

This study identifies LptM as a conserved lipoprotein that facilitates oxidative maturation of the LPS translocon by mimicking LPS binding, enabling efficient disulfide bond formation in LptD.

Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

This study uses airway organoids to investigate M. abscessus infection in CF patients, showing antioxidant pathways can inhibit bacterial growth and enhance antibiotic efficacy.

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

The paper identifies SDR enzymes as bioactivators of lipidic alkynylcarbinols, converting them into cytotoxic electrophiles that modify proteins and induce cell death.

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis

This study maps proteasome composition and interactomes during spermatogenesis, revealing structural and functional changes in the spermatoproteasome (s20S) and its role in germ cell differentiation.

Drug-bound and -free outward-facing structures of a multidrug ABC exporter point to a swing mechanism

The paper resolves two ATP-Mg2+-bound outward-facing conformations of BmrA, revealing a swing mechanism for drug transport through structural and dynamic analyses.

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependant inter-ring crosstalks

The paper uses HDX-MS to show conformational differences between human 20S proteasomes and their PA28 activators, revealing allosteric changes upon binding.

Fast and accurate bacterial species identification in biological samples using LC-MS/MS mass spectrometry and machine learning

This paper develops a method using LC-MS/MS and machine learning to rapidly identify bacterial species in clinical samples without culture, achieving 97% accuracy for UTI pathogens.