Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
S. P. Kordon, P. Dutka, J. M. Adamska, S. J. Bandekar, K. Leon, B. Adams, J. Li, A. A. Kossiakoff, D. Arac
This study develops an antibody that specifically modulates ADGRL3 function without affecting ADGRL1, demonstrating isoform- and ligand-specific aGPCR modulation.
Nature Communications · Feb 6, 2023Peer-reviewedBiochemistry