Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
M. Fareh, W. Zhao, W. Hu, J. M. Casan, A. Kumar, J. Symons, I. Voskoboinik, P. G. Ekert, R. Rudraraju, S. R. Lewin, J. A. Trapani
This study reprograms CRISPR-Cas13b to suppress SARS-CoV-2 replication and resist viral mutations by tolerating single-nucleotide mismatches.
bioRxiv · Nov 18, 2020Microbiology