Author

J. A. Trapani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

I. Voskoboinik· 3 shared A. Gifford· 1 shared A. Kumar· 1 shared A. S. Moore· 1 shared A. Senapati· 1 shared A. W. Hodel· 1 shared A. Yuksel· 1 shared B. Hoogenboom· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

I. Voskoboinik

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

C. Mayoh, A. Gifford, R. Terry, L. M. Lau, M. Wong, P. Rao, T. Shai-Hee, F. Saletta, D.-A. Khuong-Quang, V. Qin, M. Mateos, D. Meyran, K. E. Miller, A. Yuksel, E. V. Mould, , P. G Ekert

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

bioRxiv · Sep 16, 2022 · PreprintCancer Biology

The pore conformation of lymphocyte perforin

M. Ivanova, N. Lukoyanova, S. Malhotra, M. Topf, J. A. Trapani, I. Voskoboinik, H. R. Saibil

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.

bioRxiv · Jul 3, 2021Biochemistry

Lipid specificity of the immune effector perforin

A. W. Hodel, J. Rudd-Schmidt, J. A. Trapani, I. Voskoboinik, B. Hoogenboom

This study investigates how lipid composition affects perforin function using atomic force microscopy on model membranes.

Faraday Discussions · Jan 1, 2021Peer-reviewedBiophysics

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

M. Fareh, W. Zhao, W. Hu, J. M. Casan, A. Kumar, J. Symons, I. Voskoboinik, P. G. Ekert, R. Rudraraju, S. R. Lewin, J. A. Trapani

This study reprograms CRISPR-Cas13b to suppress SARS-CoV-2 replication and resist viral mutations by tolerating single-nucleotide mismatches.

bioRxiv · Nov 18, 2020Microbiology

Efficient CRISPR/Cas9 gene ablation in uncultured naive mouse T cells for in vivo studies

S. Nüssing, I. G. House, C. J. Kearney, S. J. Vervoort, P. A. Beavis, J. Oliaro, R. W. Johnstone, J. A. Trapani, I. A. Parish

This paper demonstrates efficient CRISPR/Cas9 gene ablation in uncultured naive mouse T cells for in vivo studies, showing gene deletion occurs independently of T cell activation.

bioRxiv · Aug 9, 2019Immunology