Author

I. Voskoboinik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. A. Trapani· 3 shared A. W. Hodel· 2 shared A. Kumar· 1 shared B. A. Spicer· 1 shared B. Hoogenboom· 1 shared B. W. Hoogenboom· 1 shared C. Bayly-Jones· 1 shared E. Sierecki· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

J. A. Trapani

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Author profile →

4 papers

Recent·Most cited

The pore conformation of lymphocyte perforin

M. Ivanova, N. Lukoyanova, S. Malhotra, M. Topf, J. A. Trapani, I. Voskoboinik, H. R. Saibil

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.

bioRxiv · Jul 3, 2021Biochemistry

Lipid specificity of the immune effector perforin

A. W. Hodel, J. Rudd-Schmidt, J. A. Trapani, I. Voskoboinik, B. Hoogenboom

This study investigates how lipid composition affects perforin function using atomic force microscopy on model membranes.

Faraday Discussions · Jan 1, 2021Peer-reviewedBiophysics

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

M. Fareh, W. Zhao, W. Hu, J. M. Casan, A. Kumar, J. Symons, I. Voskoboinik, P. G. Ekert, R. Rudraraju, S. R. Lewin, J. A. Trapani

This study reprograms CRISPR-Cas13b to suppress SARS-CoV-2 replication and resist viral mutations by tolerating single-nucleotide mismatches.

bioRxiv · Nov 18, 2020Microbiology

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

bioRxiv · Mar 17, 2019 · PreprintBiochemistry