Structural characterization of the PCV2d genotype at 3.3 A resolution reveals differences to PCV2a and PCV2b genotypes, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes
R. Khayat, K. Wen, A. Alimova, B. Gavrilov, A. Katz, J. M. Galarza, P. Gottlieb
The paper determines the 3.3 Å cryo-EM structure of PCV2d VLP and compares it to PCV2a and PCV2b, identifying structural changes and amino acid substitutions that may relate to vaccine response.
bioRxiv · Apr 19, 2019Biophysics