A. Katz

Elucidating early intestinal stem cell response to bacterial infection

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

Multi-target genome editing reduces polyphenol oxidase activity in wheat (Triticum aestivum L.) grains

This study uses CRISPR/Cas9 to edit multiple PPO genes in wheat, significantly reducing PPO activity in both T1 and T2 lines.

ATP1A1-linked diseases require a malfunctioning protein product from one allele

The paper investigates whether haploinsufficiency from protein-null ATP1A1 variants causes disease, finding that Atp1a1+/- mice are phenotypically normal and a human with a null variant shows no disease features.

Enhanced translation of leaderless mRNAs under oxidative stress in Escherichia coli

The paper shows that oxidative stress in E. coli inhibits canonical translation but enhances leaderless mRNA translation, mediated by (p)ppGpp.

GMO LABELING IN FOOD PRODUCTS IN MONTEVIDEO, URUGUAY

The paper analyzes GMO labeling compliance in Montevideo, Uruguay, finding 36.9% of products contained GMOs above the 1% threshold.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

Genomic analysis of the diversity, antimicrobial resistance and virulence potential of Campylobacter jejuni and Campylobacter coli strains from Chile

This study analyzes the genomic diversity, antimicrobial resistance, and virulence of Campylobacter jejuni and C. coli strains from Chile, identifying novel genetic variants and resistance patterns.

Structural characterization of the PCV2d genotype at 3.3 A resolution reveals differences to PCV2a and PCV2b genotypes, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes

The paper determines the 3.3 Å cryo-EM structure of PCV2d VLP and compares it to PCV2a and PCV2b, identifying structural changes and amino acid substitutions that may relate to vaccine response.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.