Ion channel model reduction using manifold boundaries
D. G. Whittaker, J. Wang, J. Shuttleworth, R. Venkateshappa, J. M. Kemp, T. W. Claydon, G. R. Mirams
The paper simplifies a cardiac hERG ion channel model using MBAM, reducing parameters and states while retaining predictive capability, improving parameter identifiability.
bioRxiv · Mar 11, 2022Biophysics