Author

D. G. Whittaker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:electrophysiology· 3 Approach:statistical model· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. R. Mirams· 3 shared C. L. Lei· 2 shared D. J. Gavaghan· 1 shared J. M. Kemp· 1 shared J. Shuttleworth· 1 shared J. Wang· 1 shared M. Clerx· 1 shared R. Venkateshappa· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

G. R. Mirams

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk

C. L. Lei, D. G. Whittaker, G. R. Mirams

This study evaluates how uncertainty in hERG binding mechanisms affects in silico predictions of drug-induced proarrhythmic risk.

bioRxiv · Mar 14, 2023 · PreprintBiophysics

Ion channel model reduction using manifold boundaries

D. G. Whittaker, J. Wang, J. Shuttleworth, R. Venkateshappa, J. M. Kemp, T. W. Claydon, G. R. Mirams

The paper simplifies a cardiac hERG ion channel model using MBAM, reducing parameters and states while retaining predictive capability, improving parameter identifiability.

bioRxiv · Mar 11, 2022Biophysics

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

C. L. Lei, M. Clerx, D. G. Whittaker, D. J. Gavaghan, T. P. de Boer, G. R. Mirams

This paper develops a mathematical model to explain variability in patch-clamp data by accounting for experimental artefacts rather than cell-specific ion channel kinetics.

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · May 25, 2020Peer-reviewedBiophysics