Author

J. M. Kralj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:E. coli· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. N. Bruni· 3 shared C. T. Meyer· 2 shared A. Chatterjee· 1 shared B. Dodd· 1 shared D. F. Stamo· 1 shared E. J. Miller· 1 shared G. K. Lynch· 1 shared R. Luder· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

G. N. Bruni

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Author profile →

4 papers

Recent·Most cited

High Throughput Viability Assay for Microbiology

C. T. Meyer, G. K. Lynch, D. F. Stamo, E. J. Miller, A. Chatterjee, J. M. Kralj

The paper introduces a high-throughput viability assay, GVA, that reduces time and resources compared to traditional CFU methods, enabling large-scale drug screening and discovery.

bioRxiv · Jan 4, 2023 · PreprintMicrobiology

Aminoglycosides induce a bacterial senescent state that increases antibiotic tolerance in treatment-naïve cells

C. T. Meyer, G. N. Bruni, B. Dodd, J. M. Kralj

This study shows aminoglycosides induce a bacterial senescent-like state in E. coli that increases antibiotic tolerance in untreated cells through indole secretion.

bioRxiv · Oct 4, 2021 · PreprintMicrobiology

Genome wide functional screen for calcium transients in E. coli identifies decreased membrane potential adaptation to persistent DNA damage

R. Luder, G. N. Bruni, J. M. Kralj

The paper identifies genes affecting calcium transients in E. coli through a genome-wide knockout screen, revealing distinct responses to acute and long-term DNA damage.

bioRxiv · Sep 1, 2020Microbiology

Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

G. N. Bruni, J. M. Kralj

This study shows that aminoglycoside bactericidal activity in E. coli results from hyperpolarization caused by ATP flux changes, not voltage-dependent uptake.

bioRxiv · Apr 23, 2020Microbiology