J. M. Lemme-Dumit

Repertoire of naturally acquired maternal antibodies transferred to infants for protection against shigellosis

This study measures maternal antibodies against Shigella in mother-infant pairs in Malawi, finding high placental transfer of protein-specific IgG and LPS-specific IgG, but lower SBA and OPKA activity in cord blood.

Human breast milk enhances intestinal mucosal barrier function and innate immunity in a pediatric human enteroid model

This study shows human breast milk improves intestinal barrier function and innate immunity in a pediatric enteroid model compared to commercial formula.

Epithelial and neutrophil interactions and coordinated response to Shigella in a human intestinal enteroid-neutrophil co-culture model

This paper develops an ex vivo human intestinal enteroid-PMN co-culture model to study PMN-epithelial interactions and Shigella infection responses, showing PMN phenotypic adaptation and coordinated innate immune responses.