M. Doucet

Coronin-1 is necessary for enteric pathogen-induced transcytosis across human ileal enteroid monolayers expressing M cells

This study shows that coronin 1a is required for M cell uptake and transcytosis of pathogens in human ileal enteroids, but not commensal bacteria.

Epithelial and neutrophil interactions and coordinated response to Shigella in a human intestinal enteroid-neutrophil co-culture model

This paper develops an ex vivo human intestinal enteroid-PMN co-culture model to study PMN-epithelial interactions and Shigella infection responses, showing PMN phenotypic adaptation and coordinated innate immune responses.

Epithelial WNT2B and Desert Hedgehog are necessary for human colonoid regeneration after bacterial cytotoxin injury