Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity
M. Mohrin, J. Liu, J. Zavala-Solorio, S. Bhargava, J. M. Trumble, A. Brito, D. Hu, D. Brooks, M. L. Bouxsein, R. Baron, Y. Kutskova, A. Freund
This study shows that inhibiting PAPP-A reduces collagen and ECM gene expression and modulates mesenchymal stromal cell activity in mice.
bioRxiv · Feb 5, 2020 · PreprintPhysiology