R. Baron

Social Isolation Causes Cortical and Trabecular Bone Loss in Adult Male, but not Female, C57BL/6J Mice

This study shows social isolation causes bone loss in male, but not female, mice, with different molecular mechanisms in each sex.

PTH regulates osteogenesis and suppresses adipogenesis through Zfp 467 in a feed-forward, cyclic AMP-dependent manner

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

Towns and Trails Drive Carnivore Connectivity using a Step Selection Approach

The paper uses movement models and step selection functions to estimate how human developments affect connectivity for grizzly bears and wolves in Banff National Park.

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.

Individualized System for Augmenting Ventilator Efficacy (iSAVE):A Rapidly deployable system to expand ventilator capacity

The paper introduces iSAVE, a system to safely use a single ventilator for multiple patients during ventilator shortages, demonstrating its effectiveness in simulated and pig trials.

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity

This study shows that inhibiting PAPP-A reduces collagen and ECM gene expression and modulates mesenchymal stromal cell activity in mice.

Propranolol promotes bone formation and limits resorption through novel mechanisms during anabolic parathyroid hormone treatment in female C57BL/6J mice

This study shows that propranolol enhances bone formation and reduces resorption when combined with PTH in mice, suggesting potential therapeutic benefits for low bone density.