Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament.
J. Maufront, B. Guichard, L. Y. cao, A. Di Cicco, A. JEGOU, G. Romet-Lemonne, A. Bertin
This study uses electron microscopy to directly observe two conformations of mDia1 FH2 domains interacting with actin filament barbed ends, supporting the stair stepping model.
bioRxiv · Jun 28, 2022Biophysics