A. Di Cicco

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

This study shows that the conformational changes of the bacterial ABC transporter BmrA are influenced by membrane curvature, affecting its activity and conformational states.

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate α

The paper identifies how spatial N-glycan rearrangements on α5β1 integrin nucleate galectin-3 oligomers, determining endocytic fate and retrograde trafficking.

How Myosin VI Traps its Off-State, is Activated and Dimerizes

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells

The paper identifies virus-like particles in tumor-derived extracellular vesicles and shows they differentially affect dendritic cells compared to other nanoparticles.

A specific mesh-like organization of human septin octameric complex drives membrane reshaping and curvature sensitivity

The paper investigates the organization and function of human septin octameric complexes at membranes, finding they form a mesh-like structure that drives membrane curvature sensitivity and reshaping.

Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament.

This study uses electron microscopy to directly observe two conformations of mDia1 FH2 domains interacting with actin filament barbed ends, supporting the stair stepping model.

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

This study shows that VAP-A's intrinsically disordered regions enable its versatile localization at different membrane contact sites by adjusting geometry to MCS organization and lifetime.

PI4P and BLOC-1 remodel endosomal membranes into tubules

This study shows how PI4P and BLOC-1 coordinate to form and stabilize endosomal tubules, essential for membrane remodeling and pathogen trafficking.

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

This study isolates recombinant human septin octamers with distinct SEPT9 isoforms and shows they form filament assemblies and bind actin filaments.

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact site

The paper investigates the nanoscale structure of a VAP-A-OSBP tethering complex at membrane contact sites using in vitro models and cryo-tomography.

Human ESCRT-III Polymers Assemble on Positively Curved Membranes and Induce Helical Membrane Tube Formation

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.