Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
F. A. Greco, A. Kraemer, L. Wahl, L. Elson, T. Ehret, J. Gerninghaus, J. Moeckel, S. Mueller, T. Hanke, S. Knapp
The paper designs and evaluates chemical linchpins targeting CK2α with a novel binding mode combining allosteric and ATP competitive elements, showing high selectivity and low micromolar activity.
bioRxiv · May 16, 2024Biochemistry