Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity
J. Gerninghaus, R. Zhubi, A. Kraemer, M. Karim, D. H. N. Tran, A. C. Joerger, C. Schreiber, L. M. Berger, B. T. Berger, T. A. L. Ehret, L. Elson, C. Lenz, K. Saxena, S. Mueller, S. Einav, , T. Hanke
The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.
bioRxiv · Feb 18, 2024 · PreprintBiochemistry