Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids
M. Wintzinger, M. Panta, K. Miz, A. D. P. Pragasam, M. Sargent, C. Peek, J. Bass, J. Molkentin, M. Quattrocelli
This study shows that circadian timing of glucocorticoid dosing affects heart metabolism and function through cardiomyocyte-autonomous mechanisms, with light-phase dosing improving NAD+ and ATP levels.
bioRxiv · Dec 30, 2021Physiology