Author

J. Bass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

R. Brust· 3 shared D. Kojetin· 2 shared H. Lin· 2 shared J. Shang· 2 shared P. Munoz-Tello· 2 shared S. A. Mosure· 2 shared A. A. Deniz· 1 shared A. Cano· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

R. Brust

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural basis of interdomain communication in PPARγ

S. A. Mosure, P. Munoz-Tello, K.-T. Kuo, B. MacTavish, X. Yu, D. Scholl, C. C. Williams, T. S. Strutzenberg, J. Li, J. Bass, R. Brust, E. Kalkhoven, A. A. Deniz, P. R. Griffin, D. Kojetin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

bioRxiv · Jul 13, 2022 · PreprintBiophysics

Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids

M. Wintzinger, M. Panta, K. Miz, A. D. P. Pragasam, M. Sargent, C. Peek, J. Bass, J. Molkentin, M. Quattrocelli

This study shows that circadian timing of glucocorticoid dosing affects heart metabolism and function through cardiomyocyte-autonomous mechanisms, with light-phase dosing improving NAD+ and ATP levels.

bioRxiv · Dec 30, 2021Physiology

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

J. Bass, B. Marcheva, B. J. Weidemann, A. Taguchi, M. Perelis, K. M. Ramsey, M. V. Newman, Y. Kobayashi, C. Omura, J. E. Manning Fox, H. Lin, P. E. Macdonald

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

bioRxiv · Nov 5, 2021Cell Biology

Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ

J. Shang, R. Brust, S. A. Mosure, J. Bass, P. Munoz-Tello, H. Lin, T. S. Hughes, M. Tang, Q. Ge, T. M. Kamekencka, D. J. Kojetin

The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.

bioRxiv · Nov 1, 2018Biochemistry

A structural mechanism for directing inverse agonism of PPARγ

R. Brust, J. Shang, J. Fuhrmann, J. Bass, A. Cano, Z. Heidari, I. Chrisman, A.-L. Blayo, P. Griffin, T. Kamenecka, T. Hughes, D. Kojetin

The paper shows how a phenyl-to-pyridyl substitution in PPARγ ligands converts an antagonist to an inverse agonist through a water-mediated hydrogen bond network involving Arg288.

bioRxiv · Jan 17, 2018Biochemistry