The chromatin associated Sin3B is a critical regulator of DNA damage repair through the engagement of the Non-Homologous End Joining.
J. Morales-Valencia, A. Calderon, S. Saini, G. David
This study shows Sin3B is critical for DNA damage repair by promoting non-homologous end joining through MDC1 recruitment, highlighting its role in genomic integrity and potential as a cancer therapeutic target.
bioRxiv · Mar 9, 2022 · PreprintCancer Biology