Lipocalin 2 upregulation mediates the detrimental effects of therapy-induced senescence in breast cancer cells.
J. Morales-Valencia, L. Lau, T. Marti-Nin, U. Ozerdem, G. David
This study shows that Lipocalin 2 upregulation in breast cancer cells driven by therapy-induced senescence promotes migration and reduces chemotherapy effectiveness, correlating with poor patient survival.
bioRxiv · Mar 8, 2022 · PreprintCancer Biology