Pioglitazone administration restores a PPARG-dependent transcriptional network and ATP levels within skeletal muscles of mice implanted with patient-derived breast tumors
D. A. Stanton, H. E. Wilson, M. G. Chapa, J. N. Link, W. J. Geldenhuys, E. E. Pistilli
This study shows that pioglitazone restores PPARG-dependent gene expression and ATP levels in skeletal muscles of mice with breast cancer xenografts, improving fatigue resistance.
bioRxiv · Oct 4, 2021Cancer Biology