Author

E. E. Pistilli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Assay:bulk RNA-seq· 5 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

D. A. Stanton· 3 shared H. E. Wilson· 3 shared L. E. Rentz· 2 shared M. G. Chapa· 2 shared M. Whetsell· 2 shared S. A. Clayton· 2 shared W. J. Geldenhuys· 2 shared A. D. Mizener· 1 shared

Activity by Year

2019-2024 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

D. A. Stanton

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5 papers

Recent·Most cited

Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts

S. A. Clayton, A. D. Mizener, M. Whetsell, L. E. Rentz, E. M. Meadows, W. J. Geldenhuys, E. E. Pistilli

This paper evaluates pioglitazone's effects on muscle fatigue and multi-omic profiles in breast cancer xenograft mice, finding partial restoration of lipid and mitochondrial transcriptomic dysregulation.

bioRxiv · Apr 15, 2024Cancer Biology

Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis

L. E. Rentz, M. Whetsell, S. A. Clayton, A. D. Mizner, I. Holaskova, M. G. Chapa, E. H. Hoblitzell, T. D. Eubank, E. E. Pistilli

This study examines sexual dimorphism in skeletal muscle function and molecular composition in a mouse model of breast cancer, finding sex-specific transcriptome and contractile property differences.

bioRxiv · Jun 7, 2023Cancer Biology

Pioglitazone administration restores a PPARG-dependent transcriptional network and ATP levels within skeletal muscles of mice implanted with patient-derived breast tumors

D. A. Stanton, H. E. Wilson, M. G. Chapa, J. N. Link, W. J. Geldenhuys, E. E. Pistilli

This study shows that pioglitazone restores PPARG-dependent gene expression and ATP levels in skeletal muscles of mice with breast cancer xenografts, improving fatigue resistance.

bioRxiv · Oct 4, 2021Cancer Biology

Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG

H. E. Wilson, D. A. Stanton, E. E. Pistilli

This study shows BC-derived factors impair skeletal muscle mitochondrial function and lipid metabolism, which can be reversed by PPARG activation.

American Journal of Physiology-Cell Physiology · Apr 1, 2021Peer-reviewedCancer Biology

Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype

H. E. Wilson, D. A. Stanton, C. Montgomery, A. M. Infante, M. Taylor, H. Hazard-Jenkins, E. N. Pugacheva, E. E. Pistilli

This study identifies molecular changes in skeletal muscle caused by breast cancer, showing mitochondrial dysfunction across subtypes and no effect of treatment on gene expression.

bioRxiv · Oct 21, 2019Cancer Biology