W. J. Geldenhuys

This study investigates how different aggregation states of huntingtin interact with lipid membranes and finds that oligomers are the most active, but covalent crosslinking suppresses their membrane binding and toxicity.

This study shows that pioglitazone restores PPARG-dependent gene expression and ATP levels in skeletal muscles of mice with breast cancer xenografts, improving fatigue resistance.

This study identifies mitochondrial respiration dysfunction in drug-resistant ALL cells and shows that pyrvinium pamoate (PP) effectively targets this pathway, with enhanced bioavailability and specificity for leukemic cells.