The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans
P. M. Roberts Buceta, L. Romanelli-Cedrez, S. J. Babcock, H. Xun, M. L. VonPaige, T. W. Higley, T. D. Schlatter, D. C. Davis, J. A. Drexelius, J. C. Culver, I. Carrera, J. N. Shepherd, G. Salinas
This study identifies the kynurenine pathway as a novel source of arylamine precursors essential for rhodoquinone biosynthesis in C. elegans, revealing distinct evolutionary pathways for RQ synthesis in animals versus bacteria.
bioRxiv · May 22, 2019Biochemistry