The paper identifies PSC cells in Drosophila pupae that can transdifferentiate into lamellocytes in response to wasp infection, revealing their dual role as a stem cell niche and cell reservoir.

bioRxiv · Oct 17, 2022 · PreprintCell Biology

Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity

M. Shahriyari, M. Islam, M. Sakib, A. Rika, D. Krueger, L. Kaurani, H. Anandakumar, O. Shomroni, M. Schmidt, G. Salinas, A. Unger, W. Linke, J. Zschuentzsch, J. Schmidt, A. Fischer, , M. Tiburcy

This study develops a human hypaxial muscle model from pluripotent stem cells with functional maturation and regenerative capacity for studying muscle biology and disease.

bioRxiv · Jul 12, 2021 · PreprintCell Biology

Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming upon cold exposure

M. Trajkovski, N. Hadadi, K. Steinbach, G. Salinas, D. Merkler, M. Spiljar

This study examines the tissue-specific transcriptional responses to cold exposure across multiple organs using RNA sequencing, revealing that gene expression changes are not driven by baseline expression patterns.

bioRxiv · Mar 26, 2021Physiology

The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans

P. M. Roberts Buceta, L. Romanelli-Cedrez, S. J. Babcock, H. Xun, M. L. VonPaige, T. W. Higley, T. D. Schlatter, D. C. Davis, J. A. Drexelius, J. C. Culver, I. Carrera, J. N. Shepherd, G. Salinas

This study identifies the kynurenine pathway as a novel source of arylamine precursors essential for rhodoquinone biosynthesis in C. elegans, revealing distinct evolutionary pathways for RQ synthesis in animals versus bacteria.

bioRxiv · May 22, 2019Biochemistry