Assessing target engagement using proteome-wide solvent shift assays
J. G. Van Vranken, J. Li, J. Navarrete Perea, S. P. Gygi
This paper develops solvent shift assays to assess target engagement using quantitative proteomics, showing they can identify compound targets and serve as a reliable alternative to existing methods.
bioRxiv · Jul 22, 2021Biochemistry