Author

J. G. Van Vranken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. P. Gygi· 4 shared J. Li· 2 shared A. A. Cluntun· 1 shared A. G. Toshniwal· 1 shared B. M. Spiegelman· 1 shared C. D. Dunn· 1 shared C. E. Hughes· 1 shared C. M. Sniezek· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

S. P. Gygi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

J. G. Van Vranken, J. Li, J. Mintseris, T.-Y. Wei, C. M. Sniezek, M. Gadzuk-Shea, S. P. Gygi, D. K. Schweppe

This study uses proteome-wide thermal shift assays to analyze over a million thermal stability measurements from 96 compounds in cells and 70 in lysates, revealing target engagement and off-target effects.

bioRxiv · Jan 26, 2024Biochemistry

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha

P. A. Dumesic, S. E. Wilensky, S. Bose, J. G. Van Vranken, S. P. Gygi, B. M. Spiegelman

This study identifies RBM43 as a regulator of PGC1alpha translation, linking adipose inflammation to reduced energy expenditure and mitochondrial function in obesity.

bioRxiv · Jan 6, 2023 · PreprintCell Biology

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

Y. Ouyang, C. N. Cunningham, J. A. Berg, A. G. Toshniwal, C. E. Hughes, J. G. Van Vranken, M.-Y. Jeong, A. A. Cluntun, G. Lam, J. M. Winter, E. Akdogan, K. K. Dove, S. P. Gygi, C. D. Dunn, D. R. Winge, J. Rutter

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

bioRxiv · Oct 25, 2022Cell Biology

Assessing target engagement using proteome-wide solvent shift assays

J. G. Van Vranken, J. Li, J. Navarrete Perea, S. P. Gygi

This paper develops solvent shift assays to assess target engagement using quantitative proteomics, showing they can identify compound targets and serve as a reliable alternative to existing methods.

bioRxiv · Jul 22, 2021Biochemistry