The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
H. L. Wells, M. C. Letko, G. Lasso, B. Ssebide, J. Nziza, D. K. Byarugaba, I. Navarrete-Macias, E. Liang, M. Cranfield, B. A. Han, M. W. Tingley, M. Diuk-Wasser, T. Goldstein, C. Kreuder Johnson, J. Mazet, , S. J. Anthony
This study investigates the evolutionary history of ACE2 usage in sarbecoviruses, showing that ACE2 usage in SARS-CoV-1 and SARS-CoV-2 likely arose through recombination with SARS-CoV-1 relatives, not SARS-CoV-2.
bioRxiv · Jul 7, 2020Evolutionary Biology