Author

M. C. Letko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Organism:human· 3 Organism:rat· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

V. Munster· 5 shared A. Okumura· 2 shared G. Saturday· 2 shared N. van Doremalen· 2 shared R. Fischer· 2 shared S. N. Seifert· 2 shared T. Bushmaker· 2 shared A. Li· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersMicrobiology

V. Munster

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

N. Catanzaro, Z. Wu, C. Fan, A. Schaefer, B. Yount, P. Bjorkman, R. S. Baric, M. C. Letko

The paper identifies ACE2 as a receptor for HKU5 coronaviruses from Pipistrellus abramus bats and investigates receptor tropism across merbecovirus clades.

bioRxiv · Mar 13, 2024 · PreprintMicrobiology

Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

N. van Doremalen, T. Bushmaker, R. Fischer, A. Okumura, D. Figueroa, R. J. McMinn, M. C. Letko, G. Saturday, V. Munster

This study demonstrates limited MERS-CoV transmission via aerosol, fomite, and direct contact in a transgenic human DPP4 mouse model.

bioRxiv · Nov 22, 2023Microbiology

Isolation of ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats

H. Guo, A. Li, T.-Y. Dong, H.-R. Si, H. Ben, B. Li, Y. Zhu, Z. Shi, M. C. Letko

The paper isolates ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats using a new virus isolation protocol.

bioRxiv · Mar 2, 2023 · PreprintMicrobiology

An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

S. N. Seifert, S. Bai, S. Fawcett, E. B. Norton, K. J. Zwezdaryk, J. Robinson, B. Gunn, M. C. Letko

A bat sarbecovirus uses the same cell entry route as SARS-CoV-2 but escapes vaccine immunity, highlighting the need for broader vaccines.

bioRxiv · Dec 5, 2021Microbiology

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

N. van Doremalen, M. C. Letko, R. Fischer, T. Bushmaker, K. C. Yinda, J. Schulz, S. N. Seifert, N. J. Kim, M. G. Hemida, G. Kayali, W. B. Park, R. Perera, A. Tamin, N. J. Thornburg, S. Tong, , V. Munster

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

bioRxiv · Feb 11, 2021 · PreprintMicrobiology

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

K. Rosenke, K. Meade-White, M. C. Letko, C. Clancy, F. Hansens, Y. Liu, A. Okumura, T.-L. Tang-Huau, R. Li, G. Saturday, F. Feldmann, D. Scott, Z. Wang, V. Munster, M. Jarvis, H. Feldmann

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

bioRxiv · Sep 25, 2020Microbiology

The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

H. L. Wells, M. C. Letko, G. Lasso, B. Ssebide, J. Nziza, D. K. Byarugaba, I. Navarrete-Macias, E. Liang, M. Cranfield, B. A. Han, M. W. Tingley, M. Diuk-Wasser, T. Goldstein, C. Kreuder Johnson, J. Mazet, , S. J. Anthony

This study investigates the evolutionary history of ACE2 usage in sarbecoviruses, showing that ACE2 usage in SARS-CoV-1 and SARS-CoV-2 likely arose through recombination with SARS-CoV-1 relatives, not SARS-CoV-2.

bioRxiv · Jul 7, 2020Evolutionary Biology

Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV

M. C. Letko, V. Munster

The paper assesses receptor usage and cell entry for lineage B β-coronaviruses, including 2019-nCoV, showing protease processing as a barrier and confirming ACE2 as the receptor for 2019-nCoV.

bioRxiv · Jan 22, 2020Microbiology