ImmunologybioRxivPreprint
ADA2 is a lysosomal DNase regulating the type-I interferon response
O. K. Greiner-Tollersrud, M. Krausz, E. Bartok…·M. Proietti
The paper identifies ADA2 as a lysosomal DNase that regulates the type-I interferon response by degrading cGAS/Sting-activating ligands in DADA2 patients.
DOI 10.1101/2020.06.21.162990