Secretory IgM (sIgM) is an ancient master regulator of microbiota homeostasis and metabolism
Y. Ding, A. Fernandez-Montero, A. Mani, E. Casadei, Y. Shibasaki, F. Takizawa, R. Miyazawa, I. Salinas, J. O. Sunyer
This study shows that IgM, not just sIgA and sIgT, is essential for microbiota homeostasis and metabolism in vertebrates, challenging the current understanding of sIg roles.
bioRxiv · Feb 26, 2023 · PreprintImmunology