Author

J. O. Wrabl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

V. J. Hilser· 3 shared E. B. Thompson· 1 shared J. Rives· 1 shared J. T. White· 1 shared J. Taylor· 1 shared K. Voortman-Sheetz· 1 shared M. E. Tharp· 1 shared M. H. Cho· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 14 mutual co-author links

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3 shared papersBiophysics

V. J. Hilser

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3 papers

Recent·Most cited

A Predictive Energy Landscape Model of MetamorphicProtein Conformational Specificity

J. O. Wrabl, K. Voortman-Sheetz, V. J. Hilser

This paper develops an energetic framework to predict conformational specificity of metamorphic proteins by quantifying free energy differences between native folds and denatured states, validated on the GA/GB system.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry

Tumor susceptibility gene-101 regulates glucocorticoid receptor through disorder-mediated allostery

J. T. White, J. Rives, M. E. Tharp, J. O. Wrabl, E. B. Thompson, V. J. Hilser

This study shows TSG101 regulates glucocorticoid receptor by binding its disordered N-terminal domain, enhancing DNA binding and transcriptional activity.

bioRxiv · Feb 2, 2020Biophysics

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

M. H. Cho, J. O. Wrabl, J. Taylor, V. J. Hilser

The paper develops a statistical thermodynamic framework to analyze conformational dynamics in the phosphoproteome and introduces a phosphorylation site predictor, PHOSforUS.

bioRxiv · Dec 5, 2019Biophysics