Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease
D. E. Williams, S. N. Le, D. E. Hoke, P. G. Chandler, M. Gora, M. Godlewska, J. P. Banga, A. M. Buckle
This study characterizes the structural and biophysical properties of thyroid peroxidase constructs and shows how autoantibodies bind the monomeric form, revealing conformational changes in the epitope.
bioRxiv · Dec 15, 2019Biochemistry