Author

D. E. Williams

Oak Ridge National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1 Ecology· 1 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 2 Organism:non-human primate· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. J. Andersen· 3 shared A. Baradaran-Heravi· 1 shared A. C. Baker· 1 shared A. D. Balgi· 1 shared A. M. Buckle· 1 shared Andrew D. PuttiD· 1 shared C. Aguilar· 1 shared C. D. Kenkel· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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3 shared papersBiochemistry

R. J. Andersen

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Author profile →

7 papers

Recent·Most cited

Impact of Prescribed Fire on Soil Microbial Communities in a Southern Appalachian Forest Clearcut

Sa’ad Rafie, L. R. Blentlinger, Andrew D. Putt, D. E. Williams, Dominique C. Joyner, Maria Fernanda Campa, M. J. Schubert, K. P. Hoyt, S. P. Horn, J. A. Franklin, Terry Clyde Hazen

This study examines how prescribed fires affect soil microbial communities in a Southern Appalachian forest, finding minimal short-term effects but changes in nutrient concentrations and microbial diversity.

Frontiers in Microbiology · Apr 25, 2024Peer-reviewedSystems Biology

Performance of Orbicella faveolata larval cohorts does not align with previously observed thermal tolerance of adult source populations

Y. Zhang, S. E. Gantt, E. F. Keister, H. Elder, G. Kolodziej, C. Aguilar, M. S. Studivan, D. E. Williams, D. W. Kemp, D. P. Manzello, I. C. Enochs, C. D. Kenkel

The study finds that larval thermal tolerance of Orbicella faveolata does not match the thermal tolerance of their adult source populations, challenging the assumption that tolerant parents produce tolerant offspring.

bioRxiv · Jun 28, 2023 · PreprintPhysiology

Novel Curcuphenol Analogues Possess Anti-Metastatic Biologic Activity

S. L. S. Ellis, L. L. Nohara, S. Dada, I. Saranchova, L. Munro, K. B. Choi, E. Garrovillas, C. G. Pfeifer, D. E. Williams, P. Cheng, R. J. Andersen, W. Jefferies

The paper develops water-soluble curcuphenol analogues with improved chemical properties that reverse tumour immune-escape mechanisms, reducing metastatic growth.

bioRxiv · May 15, 2023 · PreprintBiochemistry

Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane

T. Kishimoto, T. Mioka, E. Itoh, D. E. Williams, R. J. Andersen, K. Tanaka

This study shows that phospholipid flippases and Sfk1 are essential for retaining ergosterol in the yeast plasma membrane, with their disruption leading to sterol accumulation in lipid droplets.

Molecular Biology of the Cell · Jul 15, 2021Peer-reviewedCell Biology

Neighboring colonies influence uptake of thermotolerant endosymbionts in threatened Caribbean coral recruits

O. M. Williamson, C. E. Allen, D. E. Williams, M. W. Johnson, M. W. Miller, A. C. Baker

This study shows that Caribbean coral recruits can acquire thermotolerant endosymbionts from nearby donor colonies, with benefits for heat tolerance but trade-offs in growth.

bioRxiv · Nov 2, 2020Ecology

Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease

D. E. Williams, S. N. Le, D. E. Hoke, P. G. Chandler, M. Gora, M. Godlewska, J. P. Banga, A. M. Buckle

This study characterizes the structural and biophysical properties of thyroid peroxidase constructs and shows how autoantibodies bind the monomeric form, revealing conformational changes in the epitope.

bioRxiv · Dec 15, 2019Biochemistry

Gentamicin B1 is not a minor gentamicin component with major nonsense mutation suppression activity

A. Baradaran-Heravi, D. E. Williams, D. A. Powell, A. D. Balgi, R. J. Andersen, M. Roberge

The paper identifies that a previously reported gentamicin B1 compound was actually G418 and shows that true gentamicin B1 lacks PTC readthrough activity.

bioRxiv · Nov 23, 2018 · PreprintBiochemistry