Author

S. N. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. M. Buckle· 1 shared D. E. Hoke· 1 shared D. E. Williams· 1 shared D. Elmlund· 1 shared H. Elmlund· 1 shared J. P. Banga· 1 shared K. Adamus· 1 shared M. Boudes· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. M. Buckle

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2 papers

Recent·Most cited

Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease

D. E. Williams, S. N. Le, D. E. Hoke, P. G. Chandler, M. Gora, M. Godlewska, J. P. Banga, A. M. Buckle

This study characterizes the structural and biophysical properties of thyroid peroxidase constructs and shows how autoantibodies bind the monomeric form, revealing conformational changes in the epitope.

bioRxiv · Dec 15, 2019Biochemistry

AgarFix: simple and accessible stabilization of challenging single-particle cryo-EM specimens through cross-linking in a matrix of agar

K. Adamus, S. N. Le, H. Elmlund, M. Boudes, D. Elmlund

AgarFix provides a simple method to stabilize fragile protein complexes by cross-linking them in an agarose matrix, improving cryo-EM specimen preparation.

bioRxiv · Mar 6, 2019Biochemistry