Author

J. P. Barton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. K. Chakraborty· 1 shared J. O. Lloyd-Smith· 1 shared L. Dai· 1 shared M. R. McKay· 1 shared M. S. Sohail· 1 shared R. H. Y. Louie· 1 shared R. Sun· 1 shared T.-h. Zhang· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

A. K. Chakraborty

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3 papers

Recent·Most cited

A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses

Y. Gao, J. P. Barton

The paper develops a binary trait model to separate the fitness effects of HIV-1 immune escape from replication, finding that T cell escape contributes significantly to early fitness gains.

bioRxiv · Mar 3, 2024Evolutionary Biology

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

T.-h. Zhang, L. Dai, J. P. Barton, Y. Du, Y. Tan, W. Pang, A. K. Chakraborty, J. O. Lloyd-Smith, R. Sun

The paper profiles the fitness landscape of HIV-1 protease resistance mutations and finds that positive epistasis is predominant, reducing the likelihood of reversing drug resistance mutations.

bioRxiv · Oct 31, 2019Evolutionary Biology

Resolving genetic linkage reveals patterns of selection in HIV-1 evolution

M. S. Sohail, R. H. Y. Louie, M. R. McKay, J. P. Barton

This study resolves genetic linkage to analyze selection patterns in HIV-1 evolution, finding weak antibody escape selection and strong CD8+ T cell escape selection.

bioRxiv · Aug 6, 2019 · PreprintEvolutionary Biology