Author

T.-h. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

R. Sun· 2 shared Y. Du· 2 shared A. K. Chakraborty· 1 shared D. Contreras· 1 shared D. Gong· 1 shared D. Zhao· 1 shared G. Zeng· 1 shared J. O. Lloyd-Smith· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

R. Sun

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2 papers

Recent·Most cited

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

T.-h. Zhang, L. Dai, J. P. Barton, Y. Du, Y. Tan, W. Pang, A. K. Chakraborty, J. O. Lloyd-Smith, R. Sun

The paper profiles the fitness landscape of HIV-1 protease resistance mutations and finds that positive epistasis is predominant, reducing the likelihood of reversing drug resistance mutations.

bioRxiv · Oct 31, 2019Evolutionary Biology

High-throughput fitness profiling of Zika virus E protein reveals different roles for N-linked glycosylation during infection of mammalian and mosquito cells

D. Gong, T.-h. Zhang, D. Zhao, Y. Du, T. J. Chapa, Y. Shi, L. Wang, D. Contreras, G. Zeng, P.-y. Shi, T.-T. Wu, V. Arumugaswami, R. Sun

This study identifies the role of N-linked glycosylation in ZIKV E protein function across mosquito and human cells using a mutant library.

bioRxiv · Oct 8, 2017Microbiology