Cancer BiologybioRxiv
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
C. A. Nichols, W. J. Gibson, M. S. Brown…·R. Beroukhim
The paper identifies LOH of essential genes as a class of non-driver cancer vulnerabilities by showing allele-specific inactivation can selectively kill cancer cells.
DOI 10.1038/s41467-020-16399-y