Author

M. S. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

D. R. Pattabiraman· 2 shared K. E. Muller· 2 shared N. B. Ognjenovic· 2 shared A. C. Berger· 1 shared A. D. Cherniack· 1 shared B. Abdollahi· 1 shared B. Christensen· 1 shared B. R. Paolella· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

D. R. Pattabiraman

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3 papers

Recent·Most cited

Dynamic plasticity within the EMT spectrum, rather than static mesenchymal traits, drives tumor heterogeneity and metastatic progression of breast cancers

M. S. Brown, B. Abdollahi, O. M. Wilkins, P. Chakraborty, N. B. Ognjenovic, K. E. Muller, M. K. Jolly, S. Hassanpour, D. R. Pattabiraman

This study identifies intermediate EMT states in breast cancer and develops a model to quantify their role in tumor heterogeneity and metastasis.

bioRxiv · Mar 17, 2021Cancer Biology

Limiting Self-Renewal of the Basal Compartment Induces Differentiation and Alters Evolution of Mammary Tumors

N. B. Ognjenovic, M. Bagheri, G. A. Mohamed, K. Xu, M. S. Brown, Y. Chen, M. A. Mohamed Saleem, S. H. Nagaraj, K. E. Muller, B. Christensen, D. R. Pattabiraman

This study shows that PKA activation reduces self-renewal of the basal compartment, leading to less aggressive mammary tumors with increased chemotherapy sensitivity.

bioRxiv · Jan 18, 2020Cancer Biology

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

C. A. Nichols, W. J. Gibson, M. S. Brown, J. A. Kosmicki, J. P. Busanovich, H. Wei, L. M. Urbanski, N. Curimjee, A. C. Berger, G. F. Gao, A. D. Cherniack, S. Dhe-Paganon, B. R. Paolella, R. Beroukhim

The paper identifies LOH of essential genes as a class of non-driver cancer vulnerabilities by showing allele-specific inactivation can selectively kill cancer cells.

bioRxiv · Jan 29, 2019Cancer Biology