Protective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis
J. Xu, J. P. Kausalya, N. Van Hul, M. J. Caldez, S. Xu, A. G. M. Ong, W. L. Woo, S. M. Ali, P. Kaldis, W. Hunziker
This study shows that loss of Tjp2 in hepatocytes and cholangiocytes leads to cholestatic liver disease and increased susceptibility to liver injury, with protective roles in regulating bile acid transporters and detoxification enzymes.
bioRxiv · Nov 27, 2019Physiology